In this article we are going to discuss following:
What is NAD and how it's related to NMN
What are the effects of NMN;
Potential side effects of NMN;
Optimal NMN dosing.
1. What is NAD and how it's related to NMN
Before we talk about NMN, we have to understand NAD+.
NAD+ is a key molecule in every living cell. It plays critical role in energy metabolism, by carrying electrons from one reaction to another. The highest concentration of NAD is found in mitochondria, the powerhouse of the cell.
NAD is required for crucial processes:
Repairing damaged DNA
Producing energy molecules
Maintaining healthy metabolism
Maintaining healthy immune systems
Activating sirtuins
According to Dr. Siclair, as we get older we produce less and destroy more NAD. As a result, it becomes harder for out body to fight aging and associated diseases.
Also, NAD is large molecule and can’t get into the cell from outside. It has to be produced by each cell individually. There are several molecules known as NAD boosters that help to increase NAD production. Professor Sinclar research is focuses on Nicotinamide mononucleotide. He found that NMN works better that alternative compounds (i.e. NR).
2. What are the effects of NMN
NMN, in multiple animal studies, is shown to:
Increase NAD levels
Increase insulin sensitivity
Slow down effects of aging
Improve mitochondrial function
As a result of these finding, researchers hope to see further improvement. Potential benefits could include:
Lowering risk of obesity. NMN has unique potential to regulate energy metabolism and improve glucose utilization leading to stable weight as we age.
Organ protection. Professor Sinclair reports that studies shown NMN protecting damaged kidney and heart.
Improving fitness levels and muscle endurance. Our muscles depend heavily on ATP (energy molecules). NMN through increase of NAD levels can help to maintain high levels of ATP.
Protecting DNA. By maintaining healthy NAD levels, NMN activates sirtuins that protect our DNA. Studies shown that sirtuins help to repair DNA and elongate telomers further protecting DNA.
3. Potential side effects of NMN
Another important point, Dr. Sinclair reports no adverse effects with NMN administration.
Clinical study conducted in Japan evaluated safety of NMN in humans. Participants were given doses of up to 500 mg. There were no side effects reported and general tolerability profile was very good. Further research is still ongoing, but at this time there are no significant concerns over NMN supplements.
The biggest concern is cheap or fake brands of NMN. Untrustworthy, manufacturers has been claiming higher dose that actual contents of the capsules/tablets, using low quality NMN, bulking up contents with additives. To be safe choose trustworthy brands that manufacture supplements in US, have truthful ingredient list, undergone independent lab testing.
4. Optimal NMN dosing
There’s no established daily value of NMN and no consensus on the optimal dosing. However, there are new studies that try to find optimal dosing. Most recent study conducted in India evaluated safety and effectiveness of NMN in 80 healthy individuals. The most optimal dose found was 600 mg per day.
Dr. Siclair however takes 1000 mg per day. He reports administering equivalent dose to animals in his lab and found this dose to be effective.
It’s clear that further clinical studies are required to determine the most effective dosing.
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