Sirtuins are a family of proteins that play a key role in regulating various aspects of aging, such as DNA repair, inflammation, metabolism, and stress resistance. Sirtuins can only function in the presence of a molecule called NAD+, which stands for nicotinamide adenine dinucleotide. NAD+ is a coenzyme that is essential for many cellular processes, such as energy production, gene expression, and cell signaling. However, NAD+ levels decline as we age, and this impairs the activity of sirtuins and contributes to age-related diseases and conditions. Fortunately, there is a way to boost NAD+ levels and enhance sirtuin function. It is called NMN, which stands for nicotinamide mononucleotide. NMN is a precursor of NAD+, which means it can be converted into NAD+ in the body. NMN is a natural compound that is found in some foods, such as broccoli, cabbage, avocado, tomato, cucumber, and edamame. However, the amount of NMN in these foods is very low and not enough to have a significant impact on NAD+ levels. That's why taking NMN supplements can be a better option to boost your NAD+ levels and reap the benefits of sirtuins.
NMN supplements can affect sirtuins in several ways. First, NMN supplements can increase the amount of NAD+ available for sirtuins to use. This can enhance the activity of sirtuins and their ability to regulate various aspects of aging. For example, some studies have shown that NMN supplements can activate the SIRT1 gene, which is involved in DNA repair and stress resistance. Second, NMN supplements can modulate the expression of sirtuin genes. This can affect how sirtuins interact with other molecules. For example, some studies have shown that NMN supplements can upregulate the SIRT3 gene, which is involved in mitochondrial function and energy metabolism. Third, NMN supplements can influence the interactions between sirtuins and other proteins. This can affect how sirtuins regulate various cellular pathways and processes. For example, some studies have shown that NMN supplements can enhance the interaction between SIRT6 and NF-kB, which are involved in inflammation and immunity .
By affecting sirtuins in these ways, NMN supplements may have many benefits for aging and health, such as:
- Improving cognitive function and memory
- Protecting against oxidative stress and inflammation
- Enhancing insulin sensitivity and blood sugar control
- Promoting healthy skin and hair
- Extending lifespan and healthspan
If you want to experience these benefits yourself, you may want to try taking NMN supplements. However, not all NMN supplements are created equal. You need to choose a high-quality NMN supplement that has the following features:
- High purity: The NMN supplement should have over 99% purity and no artificial additives or fillers.
- High dosage: The NMN supplement should have at least 300 mg per capsule to provide an effective dose of NMN.
- High bioavailability: The NMN supplement should have a highly-absorbable form that can reach the cells and tissues where NAD+ is needed.
- High safety: The NMN supplement should be tested for quality and safety by third-party labs and comply with cGMP standards.
One of the best NMN supplements on the market that meets all these criteria is NMN Youth by Genevit. Genevit is a company that specializes in providing high-quality NMN supplements that are backed by science and customer satisfaction. Genevit's NMN Youth has over 99% purity, 300 mg per capsule, vegetarian-friendly ingredients, and free delivery. Genevit also offers a 90-day money-back guarantee, so you can try their product risk-free. If you want to boost your sirtuin function and improve your aging and health with Genevit's NMN Youth, you can order it online from the website: www.genevit.com. Don't miss this opportunity to harness the power of sirtuins with NMN!
(1) David Sinclair’s NMN & Resveratrol Protocol – Dosage & Brand. https://brainflow.co/2022/03/19/david-sinclairs-nmn-resveratrol-protocol-dosage-brand/.
(2) Nicotinamide mononucleotide (NMN) supplementation promotes .... https://pubmed.ncbi.nlm.nih.gov/32056076/.
(3) NMN (Nicotinamide Mononucleotide): Benefits, Side Effects ... - Healthline. https://www.healthline.com/health/nmn-nicotinamide-mononucleotide-benefits-side-effects-and-dosage.
(4) David Sinclair and Why He Takes NMN Supplements - And Not NR - NOVOS. https://novoslabs.com/david-sinclair-and-why-he-takes-nmn-and-not-nr/.
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